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Image Search Results
Journal: Pharmaceuticals
Article Title: Ginsenoside Rb 1 Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway
doi: 10.3390/ph18040500
Figure Lengend Snippet: ( A , B ) Evaluation of GLUT4, PPARγ, Twist1, PGC-1α, and PPARα expression on rats with HF with a quantification of the average relative density of WB data. ( C – E ) Evaluation of Twist1, PGC-1α, and PPARα expression of cardiac tissues on rats with HF by immunohistochemistry. Compared with the HF group, *** p < 0.001, ** p < 0.01, * p < 0.05.
Article Snippet: Anti- β -actin antibody (81115-1-RR, 1:5000, Proteintech, China),
Techniques: Expressing, Immunohistochemistry
Journal: Pharmaceuticals
Article Title: Ginsenoside Rb 1 Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway
doi: 10.3390/ph18040500
Figure Lengend Snippet: Ginsenoside Rb 1 alleviates ventricular remodeling in HF by regulating the Twist1/PGC-1α/PPARα signaling pathway. In the hearts of rats with HF, there is an increase in the expression of cTnT and ACTN2. Additionally, there is an elevation in atrial and ventricular pressures, accompanied by an increased secretion of ANP and BNP. Myocardial cell damage occurs, inhibiting glucose transport (reduced GLUT4 synthesis), leading to mitochondrial dysfunction. This dysfunction manifests as a decrease in MMP, reduced ATP synthesis, and decreased ETC productivity efficiency, resulting in disordered energy metabolism. Furthermore, an abnormally high expression of Twist1 is observed, which inhibits the expression of PGC-1α, PPARα, and PPARγ, thereby exacerbating cardiac injury.
Article Snippet: Anti- β -actin antibody (81115-1-RR, 1:5000, Proteintech, China),
Techniques: Expressing
Journal: Pharmaceuticals
Article Title: Ginsenoside Rb 1 Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway
doi: 10.3390/ph18040500
Figure Lengend Snippet: ( A , B ) Evaluation of GLUT4, PPARγ, Twist1, PGC-1α, and PPARα expression on rats with HF with a quantification of the average relative density of WB data. ( C – E ) Evaluation of Twist1, PGC-1α, and PPARα expression of cardiac tissues on rats with HF by immunohistochemistry. Compared with the HF group, *** p < 0.001, ** p < 0.01, * p < 0.05.
Article Snippet: Anti- β -actin antibody (81115-1-RR, 1:5000, Proteintech, China), anti-GLUT4 antibody (66846-1-1g, 1:2000, Proteintech, China), anti-PPARγ antibody (YT3836, 1:500, Immunoway, Suzhou, China), anti-Twist1 antibody (A25134, 1:1000, ABclonal, China), anti-PGC-1α antibody (ab313559, 1:1000, Abcam, Cambridge, UK), and
Techniques: Expressing, Immunohistochemistry
Journal: Pharmaceuticals
Article Title: Ginsenoside Rb 1 Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway
doi: 10.3390/ph18040500
Figure Lengend Snippet: Expression of energy metabolism protein regulated by ginsenoside Rb 1 in H9c2 cells was detected by ELISA: ( A ) Twist1, ( B ) PGC-1α, ( C ) PPARα ( n = 6). Compared with the ET-1 model group, *** p < 0.001, ** p < 0.01, * p < 0.05.
Article Snippet: Anti- β -actin antibody (81115-1-RR, 1:5000, Proteintech, China), anti-GLUT4 antibody (66846-1-1g, 1:2000, Proteintech, China), anti-PPARγ antibody (YT3836, 1:500, Immunoway, Suzhou, China), anti-Twist1 antibody (A25134, 1:1000, ABclonal, China), anti-PGC-1α antibody (ab313559, 1:1000, Abcam, Cambridge, UK), and
Techniques: Expressing, Enzyme-linked Immunosorbent Assay
Journal: Pharmaceuticals
Article Title: Ginsenoside Rb 1 Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway
doi: 10.3390/ph18040500
Figure Lengend Snippet: Ginsenoside Rb 1 alleviates ventricular remodeling in HF by regulating the Twist1/PGC-1α/PPARα signaling pathway. In the hearts of rats with HF, there is an increase in the expression of cTnT and ACTN2. Additionally, there is an elevation in atrial and ventricular pressures, accompanied by an increased secretion of ANP and BNP. Myocardial cell damage occurs, inhibiting glucose transport (reduced GLUT4 synthesis), leading to mitochondrial dysfunction. This dysfunction manifests as a decrease in MMP, reduced ATP synthesis, and decreased ETC productivity efficiency, resulting in disordered energy metabolism. Furthermore, an abnormally high expression of Twist1 is observed, which inhibits the expression of PGC-1α, PPARα, and PPARγ, thereby exacerbating cardiac injury.
Article Snippet: Anti- β -actin antibody (81115-1-RR, 1:5000, Proteintech, China), anti-GLUT4 antibody (66846-1-1g, 1:2000, Proteintech, China), anti-PPARγ antibody (YT3836, 1:500, Immunoway, Suzhou, China), anti-Twist1 antibody (A25134, 1:1000, ABclonal, China), anti-PGC-1α antibody (ab313559, 1:1000, Abcam, Cambridge, UK), and
Techniques: Expressing